Akihito Yokosuka Selected Research

nobiletin

1/2018	Nobiletin Reduces Intracellular and Extracellular β-Amyloid in iPS Cell-Derived Alzheimer's Disease Model Neurons.
7/2016	Nerve growth factor enhances the CRE-dependent transcriptional activity activated by nobiletin in PC12 cells.
8/2015	Nobiletin, a citrus flavonoid, improves cognitive impairment and reduces soluble Aβ levels in a triple transgenic mouse model of Alzheimer's disease (3XTg-AD).
1/2014	Upregulation of N-methyl-D-aspartate receptor subunits and c-Fos expressing genes in PC12D cells by nobiletin.
10/2013	Potent activity of nobiletin-rich Citrus reticulata peel extract to facilitate cAMP/PKA/ERK/CREB signaling associated with learning and memory in cultured hippocampal neurons: identification of the substances responsible for the pharmacological action.
8/2013	Suppressive effect of nobiletin, a citrus polymethoxyflavonoid that downregulates thioredoxin-interacting protein expression, on tunicamycin-induced apoptosis in SK-N-SH human neuroblastoma cells.
8/2013	Nobiletin, a citrus flavonoid, ameliorates cognitive impairment, oxidative burden, and hyperphosphorylation of tau in senescence-accelerated mouse.
2/2013	Characteristics of nobiletin-mediated alteration of gene expression in cultured cell lines.
1/2013	6-demethoxynobiletin, a nobiletin-analog citrus flavonoid, enhances extracellular signal-regulated kinase phosphorylation in PC12D cells.
1/2013	Nobiletin induces inhibitions of Ras activity and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling to suppress cell proliferation in C6 rat glioma cells.

For more, sign up at right for free...

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Akihito Yokosuka Research Topics

Disease

8	Leukemia 01/2022 - 10/2002
6	Alzheimer Disease (Alzheimer's Disease) 01/2018 - 09/2007
5	Dementia (Dementias) 01/2018 - 07/2011
4	Neoplasms (Cancer) 08/2020 - 06/2007
4	Memory Disorders (Memory Loss) 07/2016 - 09/2008
4	Cognitive Dysfunction 08/2015 - 05/2007
3	Neuroblastoma 01/2018 - 02/2013
2	Renal Cell Carcinoma (Grawitz Tumor) 01/2018 - 01/2017
2	Carcinogenesis 01/2018 - 01/2013
2	Neurodegenerative Diseases (Neurodegenerative Disease) 08/2013 - 12/2005
1	Adenocarcinoma of Lung 01/2019
1	Carcinoma (Carcinomatosis) 01/2017
1	Amyloid Plaque 08/2015
1	Hyperlipidemias (Hyperlipidemia) 02/2013
1	Hyperglycemia 02/2013
1	Glioma (Gliomas) 01/2013
1	Brain Ischemia (Cerebral Ischemia) 10/2009
1	Ischemia 10/2009
1	Nervous System Diseases (Neurological Disorders) 05/2007
1	Parasitic Diseases (Parasitic Disease) 02/2002

Drug/Important Bio-Agent (IBA)

16	nobiletinIBA 01/2018 - 12/2005
7	FlavonoidsIBA 08/2015 - 09/2007
4	Proteins (Proteins, Gene)FDA Link 01/2017 - 09/2008
3	GlycosidesIBA 01/2022 - 10/2002
3	Amyloid (Amyloid Fibrils)IBA 01/2018 - 09/2008
3	flavoneIBA 07/2016 - 01/2013
3	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 08/2015 - 05/2007
2	TriterpenesIBA 01/2022 - 09/2004
2	N-(6,7-difluoroquinolonyl)ampicillinIBA 01/2018 - 01/2017
2	SaponinsIBA 08/2009 - 09/2004
2	Pharmaceutical PreparationsIBA 05/2007 - 12/2005
1	bufadienolideIBA 08/2020
1	Adenosine Triphosphatases (ATPase)IBA 08/2020
1	pregnane glycosideIBA 01/2019
1	Neprilysin (Neutral Endopeptidase)IBA 01/2018
1	Sirtuin 1IBA 01/2018
1	Messenger RNA (mRNA)IBA 01/2017
1	ElementsIBA 07/2016
1	EnzymesIBA 05/2014
1	ThioredoxinsIBA 08/2013
1	Indicators and Reagents (Reagents)IBA 08/2013
1	Caspase 3 (Caspase-3)IBA 08/2013
1	TunicamycinIBA 08/2013
1	DNA (Deoxyribonucleic Acid)IBA 02/2013
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 01/2013
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2013
1	Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA 10/2009
1	Amyloid beta-PeptidesIBA 09/2008
1	Peptides (Polypeptides)IBA 09/2008
1	Etoposide (VP 16)FDA LinkGeneric 08/2007
1	glaziovianin AIBA 06/2007
1	IsoflavonesIBA 06/2007
1	polyglutamineIBA 12/2005
1	Oleanolic AcidIBA 09/2004
1	dehydrocorydalinIBA 02/2002

Therapy/Procedure

1	Therapeutics 10/2009